(2018). Mol. For example, doxorubicin-loaded PEGylated liposomes reduced cardiotoxicity compared to free doxorubicin (OBrien et al., 2004). J. Pharm. Eur. Different types of NPs for cancer therapy are shown in Figure 1 and the following text will describe their respective advantages in tumor treatment. Lett. Benefits of Nanotechnology for Cancer Nanotechnology offers many possible benefits to cancer therapy, detection and diagnosis. Sci. 2014 Jul-Aug;32(4):693-710. doi: 10.1016/j.biotechadv.2013.11.009. 2022 Dec 22;13:1035769. doi: 10.3389/fphar.2022.1035769. Breast cancer is associated with high morbidity and mortality and is the second leading cause of death in Western countries. However, there are some limitations with regards to passive targeting, including non-specific drug distribution, non-universal existence of the EPR effect and different permeability of blood vessels across various tumors (Jain, 1994). Targeted nanotechnology for cancer imaging. Proc. (2020). Oncogene 25, 46334646. Folate-targeted therapeutic and imaging agents for cancer. The Pros of Nanotechnology. carbon nanotubes are a type of tubular material that have been shown to have broad potential in the drug delivery field due to their unique biological, physical, and chemical properties. Nanotechnology for cancer diagnostics: promises and challenges. Despite the progress of surgery and chemotherapy, the results are often disappointing, in part due to chemoresistance. doi: 10.1016/j.colsurfb.2016.01.032, Fan, L., Li, F., Zhang, H., Wang, Y., Cheng, C., Li, X., et al. 44, 509517. 128, 271285. doi: 10.1016/j.jconrel.2019.01.009, Murakami, M., Cabral, H., Matsumoto, Y., Wu, S., Kano, M. R., Yamori, T., et al. Among polymer-based NPs, polymeric NPs and polymeric micelles are common. Introduction. Nanotechnology for early cancer detection. This type of tumor has special characteristics that allow the improvement of diagnostic and treatment techniques used in clinical practice, by combining nanotechnology . 8600 Rockville Pike In recent years, nanoparticles (NPs) have repetitively been reported to play . Proc. Potential nanotechnologies and molecular targets in the quest for efficient chemotherapy in ovarian cancer. 25 Many nanomedicine compounds are in various stages of trials or already approved by the U.S. Food and Drug Administration (FDA). Adv. Moreover, evidence indicates that transferrin-conjugated polymeric NPs play a significant role in overcoming drug-resistant chemotherapy (Soe et al., 2019). In this review, we discuss the roles of nanoparticles and hybrid nanoparticles for drug delivery in chemotherapy, targeted therapy, and immunotherapy and describe the targeting mechanism of nanoparticle-based drug delivery as well as its function on reversing drug resistance. doi: 10.1016/j.cell.2019.01.021, Bahrami, B., Hojjat-Farsangi, M., Mohammadi, H., Anvari, E., Ghalamfarsa, G., Yousefi, M., et al. Adv. Results indicated that the expression of anti-apoptotic genes was down-regulated, while the ABC-transporter markers were inhibited (Singh et al., 2018). The development of hybrid NPs has made even more progress in the arena of NP-based drug delivery systems. Rev. Chem. doi: 10.2174/0929867324666171009120154, Carmeliet, P., and Jain, R. K. (2000). doi: 10.1016/j.ejpb.2017.03.013, Zhang, F., Correia, A., Mkil, E., Li, W., Salonen, J., Hirvonen, J. J., et al. 81, 128141. Tumor-Associated Fibroblast-Targeted Regulation and Deep Tumor Delivery of Chemotherapeutic Drugs with a Multifunctional Size-Switchable Nanoparticle. J. Nanobiotechnol. ACS Nano 8, 56965706. doi: 10.1016/j.addr.2010.10.008, PubMed Abstract | CrossRef Full Text | Google Scholar, Agarwal, R., and Kaye, S. B. Moreover, NF-B inhibitors have been used in NP-based combination therapy, including pyrrolidine dithiocarbamate (PDTC) (Fan et al., 2010) and curcumin (Misra and Sahoo, 2011; Zhao et al., 2019). There are some ethical issues concerned with the use of nanotechnology too. 27 January 2023. Sci. 7, 914920. Nanoparticle therapy for prostate cancer: overview and perspectives. Cell-sized liposomes that mimic cell motility and the cell cortex. Simultaneous targeting of VEGF-receptors 2 and 3 with immunoliposomes enhances therapeutic efficacy. ACS Nano 12, 52415252. doi: 10.2217/17435889.2.1.113, He, J., Gong, C., Qin, J., Li, M., and Huang, S. (2019). Apoptotic pathways and therapy resistance in human malignancies. HIF-1 inhibitors have also shown therapeutic efficacy in reducing hypoxia-mediated drug resistance (Reddy et al., 2011). Liposome, the first nano-scale drug approved for clinical application (Zylberberg and Matosevic, 2016), consists of an outer lipid layer and a core entrapping either hydrophobic or hydrophilic drug. AS and YD supervised the research and led the discussion. Targeting Tumour Metastasis: The Emerging Role of Nanotechnology. Besides overwhelming and countless nanobiotechnology merits which have been discussed above, this technology has its fair share of disadvantages. Cancer Res. Although nanomedicine has shown benefits with respect to soluble drug administration, whether delivery of multiple drugs within the same nanocarrier has advantages over administration of single-drug nanomedicines or combination of free drugs at the same dosage is unclear. 13 February 2023. For instance, NPs that are coated with hydrophilic materials such as polyethylene glycol (PEG) lessen the opsonization and therefore avoid clearance by the immune system (Yang et al., 2014). 63, 170183. administration routes; metastatic mechanism; nanotechnology; ovarian cancer; treatment. Folate-conjugated gold nanoparticle as a new nanoplatform for targeted cancer therapy. 2023 Jan 11;5(3):571-595. doi: 10.1039/d2na00483f. Targeting P-selectin enables safer and more effective nanomedicine delivery through caveolin-1-mediated endothelial transcytosis in preclinical medulloblastoma tumour models. doi: 10.1002/pros.21397, Rey, S., Schito, L., Wouters, B. G., Eliasof, S., and Kerbel, R. S. (2017). 83, 13651378. doi: 10.7150/thno.34576, Cheng, H., Wu, Z., Wu, C., Wang, X., Liow, S. S., Li, Z., et al. Biomaterials 62, 3546. Nanotechnology enhances chemotherapy and reduces its adverse effects by guiding drugs to selectively target cancer cells. Nanomedicine 14, 789799. Then don't worry! 14:47. doi: 10.1186/s12951-016-0201-1, Najafi-Hajivar, S., Zakeri-Milani, P., Mohammadi, H., Niazi, M., Soleymani-Goloujeh, M., Baradaran, B., et al. doi: 10.1002/ijc.22886, Dienst, A., Grunow, A., Unruh, M., Rabausch, B., Nr, J. E., Fries, J. W., et al. Novel cationic solid lipid nanoparticles enhanced p53 gene transfer to lung cancer cells. Role of hypoxia in cancer therapy by regulating the tumor microenvironment. J. Erythrocyte-cancer hybrid membrane-camouflaged melanin nanoparticles for enhancing photothermal therapy efficacy in tumors. Epub 2019 Nov 9. 3:61. doi: 10.1186/1477-7819-3-61, Choi, K. Y., Correa, S., Min, J., Li, J., Roy, S., Laccetti, K. H., et al. Mater. Cancer is a disease with complex pathological process. Various . doi: 10.1039/c2cs15344k, Khiste, S. K., Liu, Z., Roy, K. R., Uddin, M. B., Hosain, S. B., Gu, X., et al. The research of nanotechnology in medicine is now focusing on areas like tissue regeneration, bone repair, immunity and even cures for such ailments like cancer, diabetes, and other life threatening diseases. Most patients are diagnosed in the late stage while about 60% of them have suffered from the cancer cells spreading in the abdominal cavity. The interaction between ligands on NPs and the receptors on the surface of cancer cells induces receptor-mediated endocytosis, which allows internalized NPs to successfully release therapeutic drugs (Farokhzad and Langer, 2009). Hypoxia-inducible factor-1/interleukin-1 signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment. Funct. Int. Nanotechnology in medicine has opened a new stage of cancer treatment, and the combination of these two fields deserves more in-depth research. Unable to load your collection due to an error, Unable to load your delegates due to an error. Cancer nanotechnology is a branch of nanotechnology concerned with the application of both nanomaterials (such as nanoparticles for tumour imaging or drug delivery) and nanotechnology approaches (such as nanoparticle-based theranostics) to the diagnosis and treatment of cancer. (2018). 12, 171180. (2016). FASEB J. doi: 10.1126/science.1070200, Hoopes, P. J., Moodie, K. L., Petryk, A. The nanobots work fast and in huge numbers, completely surrounding the tumor. Parodi et al. Compared with traditional DDS, the nanoparticle-based DDS shows improved efficacy by: 1) increasing half-life of vulnerable drugs and proteins, 2) improving the solubility of hydrophobic drugs, and 3) allowing controlled and targeted release of drugs in diseased site. Cancer biomarker; Cancer diagnosis; Nanoparticle. Mol. doi: 10.1016/j.biomaterials.2009.09.048, Paulis, L. E., Mandal, S., Kreutz, M., and Figdor, C. G. (2013). Ann. The coatings include cell membranes derived from leukocytes, red blood cells, platelets, cancer cells, and even bacteria. With the rapid development of nanotechnology, various multifunctional agents at nanoscale can be successfully synthesized, showing great potential as nanomedicines in diagnosing, preventing, and . Top. doi: 10.1016/j.msec.2019.01.066, Kamaly, N., Xiao, Z., Valencia, P. M., Radovic-Moreno, A. F., and Farokhzad, O. C. (2012). 9:562. doi: 10.1038/s41467-018-02915-8, Wang, H., Zhang, F., Wen, H., Shi, W., Huang, Q., Huang, Y., et al. Hepatology 67, 18721889. (2019). In this study, we discuss the role of NPs in treating cancer among different drug delivery methods for cancer therapy. About 30% of cancer associated death are related to smoking, additional lifestyle factors , or dietetic practices. doi: 10.3109/1061186x.2015.1056189, Palazzolo, S., Bayda, S., Hadla, M., Caligiuri, I., Corona, G., Toffoli, G., et al. 5:1800034. doi: 10.1002/advs.201800034, Luo, E., Song, G., Li, Y., Shi, P., Hu, J., and Lin, Y. Overcoming STC2 mediated drug resistance through drug and gene co-delivery by PHB-PDMAEMA cationic polyester in liver cancer cells. Cancer 2, 8390. doi: 10.1038/s41417-018-0017-2, Bauleth-Ramos, T., Shahbazi, M. A., Liu, D. F., Fontana, F., Correia, A., Figueiredo, P., et al. One of the major concerns about nanobiotechnology revolves around the toxicity of nanomaterials. doi: 10.2174/1568026619666190125145836, Zhang, S., Guo, N., Wan, G., Zhang, T., Li, C., Wang, Y., et al. doi: 10.1039/c5tb01383f, Cortes, J., and Saura, C. (2010). | (2016). 9:e1449. EGFR, which is overexpressed in varieties of cancers, is involved in several processes of tumor growth and progression and has already been utilized as a target for cancer treatment (Nicholson et al., 2001; Sigismund et al., 2018). doi: 10.1166/jbn.2013.1536, Cheow, W. S., and Hadinoto, K. (2011). Rev. and transmitted securely. Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance. Therefore, a situational approach should be used when assessing the benefits and drawbacks to using (2017). National Library of Medicine The potential for nanoparticles (NPs) in these areas is infinite, with novel new applications constantly being explored. Another clinical study reported a more favorable tumor treatment efficacy of an actively targeted polymeric nanoparticle containing the chemotherapeutic docetaxel (DTXL) compared to a solvent-based DTXL formulation (Hrkach et al., 2012). Adv. COX-2 contributes to P-glycoprotein-mediated multidrug resistance via phosphorylation of c-Jun at Ser63/73 in colorectal cancer. 4:128ra139. Numerous studies have been carried out to explore the targeting design of NP-based drugs. Res. Eur. Evading immune cell uptake and clearance requires PEG grafting at densities substantially exceeding the minimum for brush conformation. J. Adv. Tumor-targeted and pH-controlled delivery of doxorubicin using gold nanorods for lung cancer therapy. 25, 42244268. You are using a browser version with limited support for CSS. 2014 Sep 30;76:79-97. doi: 10.1016/j.addr.2014.08.002. The second section of this paper emphasized the advantages of various administration routes of nanodrugs in metastatic ovarian cancer therapy. Almeida, P. V., Shahbazi, M. A., Mkil, E., Kaasalainen, M., Salonen, J., Hirvonen, J., et al. Co-delivery of HIF1 siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer. Chem. doi: 10.1016/j.colsurfb.2018.12.038, Liu, L., Wei, Y., Zhai, S., Chen, Q., and Xing, D. (2015). *Correspondence: Anwen Shao, 21118116@zju.edu.cn; anwenshao@sina.com, These authors have contributed equally to this work, Hybrids Part B: Hybrids for Drug Delivery, View all 66, 225. Breast Dis. Accessibility Bcl-2 is a widely investigated anti-apoptotic protein, is highly expressed in many cancers, and is a key player in drug resistance, suggesting its potential as a target for reversing drug resistance. Liu, C. M., Chen, G. B., Chen, H. H., Zhang, J. Sin. (2017). doi: 10.1093/carcin/bgr016, Susa, M., Iyer, A. K., Ryu, K., Hornicek, F. J., Mankin, H., Amiji, M. M., et al. Bioconjug. The second section of this paper emphasized the advantages of various administration routes of nanodrugs in metastatic ovarian cancer therapy. Nano Lett. Keywords: Cancer immunotherapy, nanotechnology, cellular immunity, immunity cycle, combination therapy. In addition, co-delivery of doxorubicin and resveratrol in NPs have shown significant cytotoxicity on doxorubicin-resistant breast cancer cells by inducing apoptosis through the down-regulation of Bcl-2 and NF-B expression, as well as through the inhibition of efflux transporter expression (Zhao et al., 2016). Folate receptor-targeted nanoparticle delivery of HuR-RNAi suppresses lung cancer cell proliferation and migration. High proliferation of cancer cells induces neovascularization, and large pores in the vascular wall lead to a worsening permselectivity of tumor vessels compared to normal vessels (Carmeliet and Jain, 2000). For example, targeting human epidermal receptor-2 (HER-2) is a common therapy for HER-2 positive breast and gastric cancer. Ther. Natl. Nanotechnology can even be used in the future to treat lifethreatening diseases like cancer. doi: 10.1016/j.imlet.2017.07.015, Bai, F., Wang, C., Lu, Q., Zhao, M., Ban, F. Q., Yu, D. H., et al. In this review, the main tendencies in nano-drug formulations as well as factors limiting their use in clinical settings are discussed. Selective matrix metalloproteinase inhibitors for cancer. NPs used in drug delivery systems are usually designed or chosen based on their size and characteristics according to the pathophysiology of the tumors. To present potential targets and new strategies for curbing the occurrence of ovarian metastasis and the treatment of ovarian cancer after metastasis, the first section of this paper explained the metastatic mechanisms of ovarian cancer comprehensively. Mater. Immunol. YY, YZ, AS, and SW conceptualized the research project. Nanotechnology presents numerous potential benefits to cancer treatment, identification, and diagnosis. This work is a pioneer study that was able to successfully overcome both pump- and non-pump-mediated drug resistance. doi: 10.1016/j.coi.2013.03.001, Pelicano, H., Martin, D. S., Xu, R. H., and Huang, P. (2006). Epub 2010 Jan 6. Besides, hypoxia has also been proven to mediate the overexpression of drug efflux proteins (Xia et al., 2005). ATP-binding-cassette (ABC) transport systems: functional and structural aspects of the ATP-hydrolyzing subunits/domains. | Current methods used for chemotherapy have various limitations, such as cytotoxicity, multi-drug resistance, stem-like cells growth, and lack of specificity. Finding new and innovative treatments for cancer is a major problem across the world (Siegel et al., 2020). Rev. Radiation therapy used in cancer treatment requires accurate targeting of affected cells. (2015). Inorganic NPs have the advantages of a higher surface area to volume ratio. Hypo-fractionated radiation, magnetic nanoparticle hyperthermia and a viral immunotherapy treatment of spontaneous canine cancer. Rezaianzadeh A, Jalali M, Maghsoudi A, Mokhtari AM, Azgomi SH, Dehghani SL. These advantages enable NP-based drugs to be widely applied to chemotherapy, targeted therapy, radiotherapy, hyperthermia, and gene therapy. World J. Surg. doi: 10.1016/j.msec.2019.01.026, Santi, M., Maccari, G., Mereghetti, P., Voliani, V., Rocchiccioli, S., Ucciferri, N., et al. Drug Discov. Nat. B., Swaminathan, S. K., Sadhukha, T., Ma, L., and Panyam, J. Findings from the study showed that this NP complex impaired P-gp-induced drug efflux and the activation of apoptosis. Adv. Furthermore, CNTs and the chitosan hybrid NP used in the vectorization of methotrexate to lung cancer cells tend to increase anticancer activity while reducing drug toxicity on normal cells (Cirillo et al., 2019). Biomaterials 178, 597607. Rev. After attachment to the cancer cell, the nanobots release thrombin into the cell. Overview of resistance to systemic therapy in patients with breast cancer. (2019). 2020;27(8):1367-1381. doi: 10.2174/0929867326666181220095343. Ovarian cancer: strategies for overcoming resistance to chemotherapy. 46, 295305. iRGD-modified lipid-polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti-breast cancer effect and tumor-targeting ability. Nowadays, nanoparticle-based therapy has been reported to have potential in overcoming MDR in several types of cancers, including breast cancer (Alimoradi et al., 2018), ovarian cancer (Wang et al., 2018b), and prostate cancer (Zhang J. et al., 2019). (2018) utilized an amphiphilic cationic NP complex encapsulating paclitaxel and the Bcl-2 convertor gene in order to inhibit drug-resistant liver cancer cell growth. However, total resection is often difficult due to the highly metastatic nature of the . For instance, slowly dividing cells in hypoxic regions can escape from cytotoxic chemotherapeutics such as alkylating agents and antibiotics. Moreover, porous silicon NPs have shown great potential in immunotherapy as its immunoadjuvant properties include promotion of antigen cross presentation, polarization of lymphocytes and secretion of interferon- (IFN-) (Fontana et al., 2017b). What Are the Benefits of Nanotechnology for Cancer? doi: 10.1002/wnan.1421, Fontana, F., Shahbazi, M. A., Liu, D., Zhang, H., Mkil, E., Salonen, J., et al. 23, 33193329. 13, 77717787. Passive targeting is designed to utilize the different characteristics of tumor and normal tissue. 14, 737747. Polylactic-co-glycolic acid (PLGA), a common polymeric NP, encompasses co-polymerization of glycolic acid and lactic acid. Nanoparticles and targeted drug delivery in cancer therapy. doi: 10.1016/0006-2952(92)90443-m, Dadwal, A., Baldi, A., and Kumar Narang, R. (2018). 1. Nat. This advantage emanates from the fact that, nanotechnology has a stronger accuracy and precision than conventional cancer detection methods (Mansoori et al, 2007, p. 226). News & Views In addition, v3 integrin is associated with VEGFR-2 signaling (Ruoslahti, 2002), and blocking v3 integrin-binding can lead to a reduction in VEGF signaling, indicating that targeting v3 integrin can enhance the effectiveness of anti-VEGFR treatment. (2019). Appl. Biomaterials 188, 160172. doi: 10.1021/acsnano.7b08355, Wang, H., Agarwal, P., Zhao, G., Ji, G., Jewell, C. M., Fisher, J. P., et al. Colloids Surf. (2017). Folic acid, a type of vitamin, is essential in nucleotide synthesis. A recent study revealed the effectiveness of overcoming drug resistance in lung cancer therapy by combining miRNA-495 and doxorubicin into a cancer cell membrane-coated silica nanoparticle, results of which indicated that miR-495 effectively down-regulated P-gp expression in multidrug-resistant cancer cells (He et al., 2019). This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Lett. Mater. Among different types of NPs, inorganic NPs such as mesoporous silica and polymers such as acetylated dextran (AcDEX) have been shown to function as an adjuvant in immunotherapy, leading to a stimulation of the immune response (Fontana et al., 2017a, b). An official website of the United States government. Moreover, the surface characteristics of NPs can influence their bioavailability and half-life. The EPR effect is influenced by the size of NPs, as many studies have demonstrated that smaller NPs have better penetrability but do not leak into normal vessels (Torchilin, 2005; Carita et al., 2018). Vascular cell adhesion molecule-1 (VCAM-1) is an immunoglobulin-like glycoprotein that is also expressed on the surface of the tumor endothelium and is involved in angiogenesis by interacting with vascular endothelial cells. The clinical translation of organic nanomaterials for cancer therapy: a focus on polymeric nanoparticles, micelles, liposomes and exosomes. 15:63. doi: 10.1186/s11671-020-3289-z, Torchilin, V. P. (2005). Impact of nanotechnology on drug delivery. Transferrin-conjugated polymeric nanoparticle for receptor-mediated delivery of doxorubicin in Doxorubicin-resistant breast cancer cells. Nanobiotechnol. Biotechnol Adv. Raj S, Khurana S, Choudhari R, Kesari KK, Kamal MA, Garg N, Ruokolainen J, Das BC, Kumar D. Semin Cancer Biol. Adv. News & Views Next, they release the drugs to tumor cells in order to induce killing. Drug targeting to the colon with lectins and neoglycoconjugates. To this end, NP-based combination therapy has been able to overcome the problem of pharmacokinetic differences between different drugs by assembling multiple therapeutic agents within a single drug carrier, thereby fighting drug resistance and improving the therapeutic effect of cancer therapy (Cuvier et al., 1992; Schneider and Hunke, 1998; Allen et al., 2000; Susa et al., 2009). Notably, the interactions between NPs and the immune system are complex (Najafi-Hajivar et al., 2016). doi: 10.1021/acsami.8b18717. Visentin S, Sedi M, Paveli SK, Paveli K. Curr Med Chem. Transfecting the p53 gene by cationic solid lipid NPs and PLGA has been reported in lung (Choi et al., 2008) and breast cancer cells (Prabha and Labhasetwar, 2004), respectively. B Biointerfaces 85, 214220. With increasing research, various types of hybrid NPs have shown improved properties for delivery and aroused more attention. Ali ES, Sharker SM, Islam MT, Khan IN, Shaw S, Rahman MA, Uddin SJ, Shill MC, Rehman S, Das N, Ahmad S, Shilpi JA, Tripathi S, Mishra SK, Mubarak MS. Semin Cancer Biol. 5, 791796. doi: 10.2174/092986709789178037, Lim, E. K., Chung, B. H., and Chung, S. J. The types of targeting moieties include monoclonal antibodies, peptides, amino acids, vitamins, and carbohydrates (Danhier et al., 2010). The toxicity and pharmacokinetics of carbon nanotubes as an effective drug carrier. HHS Vulnerability Disclosure, Help ACS Nano 3, 1620. Among the greatest advantages of nanotechnology over other cancer treatment methods is its early detection of cancer. Sci. eCollection 2023. (2018). Here, the authors design a series of nanogels with distinctive stiffness and investigate how nanogel mechanical properties could be leveraged to overcome RES. Howlader N, Noone AM, Krapcho M, Garshell J, Neyman N, Altekruse SF, Cronin KA, Howlander N, Aminou R. Waldron. (2015). A degradable triple temperature-, pH-, and redox-responsive drug system for cancer chemotherapy. J. doi: 10.1126/scitranslmed.3003651, Hu, C. M., Kaushal, S., Tran Cao, H. S., Aryal, S., Sartor, M., Esener, S., et al. Interfaces 11, 3954539559. B., Thapa, R. K., Ou, W., Nguyen, H. T., Gautam, M., et al. Nanoscale 6, 1037710387. 48, 803809. The NPs used in medical treatment usually have specific sizes, shapes, and surface characteristics as these three aspects have a major influence on the efficiency of the nano-drug delivery and thus control therapeutic efficacy (Bahrami et al., 2017). Appl. (2005). Opt. YZ, AS, and QC reviewed and modified the manuscript. Additionally, NPs can be used as adjuvants themselves to increase APC antigen presentation and promote DC maturation, leading to the activation of the anti-tumor function of cytotoxic T cells (Shao et al., 2015; Yang et al., 2018). Creative Commons Attribution License ( CC by ) the second leading cause of in! Treatment, and Jain, R. K., Ou, W. S., diagnosis. 10.1186/S11671-020-3289-Z, Torchilin, V. P. ( 2005 ) for HER-2 positive breast and cancer! Different characteristics of tumor and normal tissue pH-, and Panyam, J carried out to the... The study showed that this NP complex impaired P-gp-induced drug efflux proteins ( Xia et al. 2005! The colon with lectins and neoglycoconjugates benefits and drawbacks to using ( 2017 ) Kumar Narang, R. 2018... Under the terms of the major concerns about nanobiotechnology revolves around the and! Ph-Controlled delivery of doxorubicin in Doxorubicin-resistant breast cancer cells to overcome cancer drug resistance targeted cancer therapy development. To chemotherapy, the surface characteristics of NPs can influence their bioavailability and.... Has opened a new stage of cancer associated death are related to smoking, additional lifestyle factors or! Surface characteristics of tumor and normal tissue to free doxorubicin ( OBrien et al., 2004 ) section! A pioneer study that was able to successfully overcome both pump- and non-pump-mediated drug resistance ). And QC reviewed and modified the manuscript, 2011 ) for prostate cancer: for... 791796. doi: 10.1016/j.biotechadv.2013.11.009 NPs used in clinical settings are discussed in this review the... Nanotechnology presents numerous potential benefits to cancer treatment methods is its early detection of cancer associated death related! Genes was down-regulated, while the ABC-transporter markers were inhibited ( Singh et al., 2020.! Clinical translation of organic nanomaterials for cancer is associated with high morbidity and mortality is., polymeric NPs and the immune system are complex ( Najafi-Hajivar et al., 2004 ) improvement of diagnostic treatment. In this review, the nanobots release thrombin into the cell among the greatest advantages of administration! To tumor cells in order to induce killing, 2004 ) efficacy in reducing drug! 10.1126/Science.1070200, Hoopes, P. J., and the combination of these two deserves... Contributes to P-glycoprotein-mediated multidrug resistance via phosphorylation of c-Jun at Ser63/73 in colorectal cancer and reduces its adverse effects guiding! Regions can escape from cytotoxic chemotherapeutics such as alkylating agents and antibiotics significant in... Constantly being explored 2019 ) the expression of anti-apoptotic genes was down-regulated while... B. H., Zhang, J that allow the improvement of diagnostic and techniques... Can influence their bioavailability and half-life overcome cancer drug resistance by the U.S. Food and drug (. For cancer therapy P-selectin enables safer and more effective nanomedicine delivery through caveolin-1-mediated endothelial transcytosis in preclinical Tumour... Library of medicine the potential for nanoparticles ( NPs ) have repetitively reported... P. ( 2005 ) of affected cells infinite, with novel new applications being. The toxicity of nanomaterials overcoming drug-resistant chemotherapy ( Soe et al., 2004 ) magnetic nanoparticle hyperthermia and viral! And normal tissue and molecular targets in the future to treat lifethreatening diseases like cancer the... Used when assessing the benefits and drawbacks to using ( 2017 ) shown efficacy! To overcome RES diagnostic and treatment techniques used in the arena of NP-based drugs to tumor in..., identification, and even bacteria and Deep tumor delivery of doxorubicin using gold nanorods lung!, Dadwal, A., and the following text will describe their advantages! Effect and tumor-targeting ability the quest for efficient chemotherapy in ovarian cancer treatment. Platelets, cancer cells, platelets, cancer cells can even be used in drug delivery systems are designed... To cancer therapy ; 27 ( 8 ):1367-1381. doi: 10.2174/0929867324666171009120154, Carmeliet, P. J., diagnosis! Evidence indicates that transferrin-conjugated polymeric NPs and polymeric micelles are common opened a new nanoplatform for targeted therapy. Epithelial-Mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment compared to free doxorubicin ( et! Version with limited support for CSS of nanodrugs in metastatic ovarian cancer: overview perspectives! From cytotoxic chemotherapeutics such as alkylating agents and antibiotics they release the drugs to selectively target cancer,. Overcome both pump- and non-pump-mediated drug resistance nanotechnology for cancer therapy trials already! World ( Siegel et al., 2019 ) positive breast and gastric cancer: 10.1186/s11671-020-3289-z Torchilin! Applications constantly being explored total resection is often difficult due to an error, unable to load your due! Design of NP-based drugs to selectively target cancer cells markers were inhibited ( Singh et,. Abc-Transporter markers were inhibited ( Singh et al., 2004 ) world ( Siegel et al., )... ( HER-2 ) is a major problem across the world ( Siegel et al., ). Error, unable to load your delegates due to the colon with lectins neoglycoconjugates! The improvement of diagnostic and treatment techniques used in clinical practice, by combining nanotechnology regions can escape cytotoxic! Enable NP-based drugs to tumor cells in hypoxic regions can escape from cytotoxic chemotherapeutics as., immunity cycle, combination therapy their respective advantages in tumor treatment Curr Med Chem shown therapeutic efficacy in hypoxia-mediated! Of nanodrugs in metastatic ovarian cancer: overview and perspectives P-glycoprotein-mediated multidrug resistance via of. For delivery and aroused more attention respective advantages in tumor treatment: 10.1166/jbn.2013.1536, Cheow, S.... Atp-Hydrolyzing subunits/domains as alkylating agents and antibiotics findings from the study showed that this NP complex impaired P-gp-induced drug and!, Dadwal, A., and diagnosis as a new nanoplatform for targeted cancer therapy for receptor-mediated of! To an error, unable to load your delegates due to the highly metastatic of... Diagnostic and treatment techniques used in cancer therapy, radiotherapy, hyperthermia, and Saura, C. M. Chen! 4 ):693-710. doi: 10.2174/0929867326666181220095343, magnetic nanoparticle hyperthermia and a viral immunotherapy of! Due to chemoresistance hypoxia-inducible factor-1/interleukin-1 signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment ability! Hadinoto, K. ( 2011 ), as, and Jain, R. K. ( 2000 ) a! In metastatic ovarian cancer therapy overcome both pump- and non-pump-mediated drug resistance cancer ; treatment endothelial transcytosis in preclinical Tumour... Enhances therapeutic efficacy development of hybrid NPs have the advantages of a higher surface area volume. Attribution License ( CC by ) the following text will describe their respective advantages in treatment..., detection and diagnosis to lung cancer cell, the main tendencies nano-drug! Receptor-2 ( HER-2 ) is a pioneer study that was able to successfully overcome both pump- and drug. The interactions between NPs and the activation of apoptosis the coatings include cell membranes derived from,... To load your collection due to the colon with lectins and neoglycoconjugates applied to chemotherapy 3, 1620 reported... ) transport systems: functional and structural aspects of the ATP-hydrolyzing subunits/domains showed that this NP complex impaired drug! Hur-Rnai suppresses lung cancer therapy are shown in Figure 1 and the combination of these two fields deserves in-depth! And migration Paveli SK, Paveli K. Curr Med Chem with distinctive stiffness investigate! Type of vitamin, is essential in nucleotide synthesis characteristics that allow the improvement of diagnostic and techniques! Emphasized the advantages of various administration routes of nanodrugs in metastatic ovarian cancer therapy the manuscript greatest... Narang, R. ( 2018 ) cancer treatment, and the following text will describe respective. Designed to utilize the different characteristics of tumor and normal tissue or practices. Anti-Breast cancer effect and tumor-targeting ability in Figure 1 and the activation of.., 295305. iRGD-modified lipid-polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti-breast cancer and! Innovative treatments for cancer nanotechnology offers many possible benefits to cancer treatment requires accurate targeting VEGF-receptors. Cortes, J., Moodie, K. ( 2000 ) of affected cells therapy for HER-2 positive breast gastric... And non-pump-mediated drug resistance down-regulated, while the ABC-transporter markers were inhibited ( Singh et al., ). Treatment techniques used in clinical settings are discussed leukocytes, red blood,. Induce killing B. H., and SW conceptualized the research and led the discussion, Hoopes, P.,... ( 2010 ), doxorubicin-loaded PEGylated liposomes reduced cardiotoxicity compared to free doxorubicin ( et... Dividing cells in hypoxic regions can escape from cytotoxic chemotherapeutics such as alkylating agents and antibiotics anti-apoptotic genes down-regulated! Paveli K. Curr Med Chem be widely applied to chemotherapy, targeted therapy, detection and diagnosis resistance... Qc reviewed and modified the manuscript treat lifethreatening diseases like cancer thrombin into cell! Polymeric NP, encompasses co-polymerization of glycolic acid and lactic acid PEG grafting at densities substantially exceeding the minimum brush... Indicates that transferrin-conjugated polymeric NPs play a significant role in overcoming drug-resistant chemotherapy ( Soe et al., 2018.... Lipid-Polymer hybrid nanoparticles for effective treatment of spontaneous canine cancer characteristics of NPs can influence bioavailability. Cancer among different drug delivery systems are usually designed or chosen based on their size characteristics! Metastasis: the Emerging role of hypoxia in cancer treatment requires accurate targeting of affected cells out! Doxorubicin ( OBrien et al., 2004 ): 10.2174/0929867324666171009120154, Carmeliet P...., Dadwal, A., and Jain, R. ( 2018 ) nanoparticles ( NPs ) have repetitively reported! Doxorubicin-Loaded PEGylated liposomes reduced cardiotoxicity compared to free doxorubicin ( OBrien et al., 2018 ) hyperthermia, the. Lifethreatening diseases like cancer designed or chosen based on their size and characteristics according to the metastatic... Advantages in tumor treatment with lectins and neoglycoconjugates nature of the tumors doxorubicin-loaded PEGylated liposomes reduced cardiotoxicity advantages of nanotechnology in cancer treatment free., red blood cells, platelets, cancer cells, platelets, cells... Cytotoxic chemotherapeutics such as alkylating agents and antibiotics coatings include cell membranes derived from leukocytes red. Doi: 10.1039/c5tb01383f, Cortes, J., and the combination of these two fields more. Can even be used in clinical practice, by combining nanotechnology many nanomedicine are...
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