WebBifidobacterium longum subsp. Additional test tubes can be inoculated by transferring 0. Another study stated that B. longum KACC 91563 exists favorable impacts on increase of the SCFA content in feces of normal dogs and improves the gut microbiota structure [101]. It has immune tolerance to the human body and will not cause rejection [15]. 139, pp. Billion, and F. Tacchini-Cottier, The impact of neutrophil recruitment to the skin on the pathology induced by Leishmania infection, Frontiers in Immunology, vol. W. S. Song, H. G. Park, S. M. Kim et al., Chemical derivatization-based LC-MS/MS method for quantitation of gut microbial short-chain fatty acids, Journal of Industrial and Engineering Chemistry, vol. Often, they may feel like hard lumps under the skin, Inflammation and an increase in synovial fluid within the joint may cause swelling, Joints may not move as freely or as far as normal, Joints may hurt during of after movement or at the end of the day, Movement of the joint may cause a crackling or grating sensation, Joints may feel tender when light pressure is applied. 829837, 2018. As the final products of anaerobic intestinal microbiota fermentation, SCFAs have beneficial effects in accelerating intestinal movement and modulating the body immune system. It contains trillions of microbes, which are usually called gut microbiota [17, 18]. 128142, 2018. Bifidobacterium longum and inulin-oligofructose were provided to UC patients. WebBifidobacterium longum D2957 Bifidobacterium longum DJO10A Bifidobacterium longum E18 Bifidobacterium longum NCC2705 Bifidobacterium longum subsp. IBD treatment targeting the gut microbiome, Pathogens, vol. H. in Kim, J. K. Kim, J. Y. Kim, S. E. Jang, M. J. Han, and D. H. Kim, Lactobacillus plantarum LC27 and Bifidobacterium longum LC67 simultaneously alleviate high-fat diet-induced colitis, endotoxemia, liver steatosis, and obesity in mice, Nutrition Research, vol. Bifidobacterium and lactobacillus is a medical food used as a probiotic, or "friendly bacteria" to maintain a healthy digestive tract (stomach and intestines). 4, pp. Bifidobacterium can be stably colonized in the human intestine. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. A. Hastreiter, A. S. Mello et al., The effects of protein malnutrition on the TNF-RI and NF-B expression via the TNF- signaling pathway, Cytokine, vol. 112, no. Although traditionally regarded as a disease prevalent in Western countries, the incidence of IBD is gradually increasing globally, especially in newly industrialized countries [2]. Unauthorized use of these marks is strictly prohibited. The aim of the present study was to investigate the potential of bifidobacteria in protecting cells from coxsackievirus B4 (CV-B4) infection. The https:// ensures that you are connecting to the 7, no. 2 active sites 1 reviewed publication. Europe PMC is an archive of life sciences journal literature. Dysbiosis: Adverse alterations in the diversity, structure or function of gut microbiota that is associated with disease, Bifidobacterium longum CBi0703 has been fully characterised and selected for use in osteoarthritis based on its immunomodulatory properties 13 14, 320 male and females with mild-moderate osteoarthritis, 1 capsule/day (Bifidobacterium longum CBi0703 + Vitamin C), Pamex LimitedMoneen Business ParkCastlebarCo. It produces lactic and acetic acid in the gut. The disease can be alleviated by the neutralizing effect of TNF- [51, 60, 61]. 5, pp. FOIA 2021 Dec;13(2_suppl):1204S-1213S. 6, pp. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you. Bifidobacteria are members of the intestinal microbiota of mammals and other animals, and some strains are able to exert health-promoting effects. They can also increase the risk of metabolic syndrome and reduce plasma cholesterol levels [99, 100] (Figure 1). Feeding mice with Bifidobacterium longum strains Bif10 and Bif16 could reduce their crypt deformation, diarrhea, etc. High bone density has been found to be associated with OA at the knee and hip. 856860, 1998. The in silico molecular docking study using CV-B3 as template showed low-energy binding, indicating a stable system for the selected peptides and consequently a likely binding interaction with CV-B. It can resist pathogenic microorganisms and harmful substances in the intestinal environment to avoid damage [85]. Y. Gu, G. Zhou, X. Qin, S. Huang, B. Wang, and H. Cao, The potential role of gut mycobiome in irritable bowel syndrome, Frontiers in Microbiology, vol. 10, no. 8, p. 2353, 2020. 655666, 2019. Bifidobacteria secreting lipoproteins protect HEp-2 cell against coxsackievirus B4. S. Yan, B. Yang, J. C. Zhao et al., A ropy exopolysaccharide producing strainBifidobacterium longumsubsp.longumYS108R alleviates DSS-induced colitis by maintenance of the mucosal barrier and gut microbiota modulation, Food & Function, vol. Y. Wang, C. E. Parker, B. G. Feagan, and J. K. Macdonald, Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis, Cochrane Database of Systematic Reviews, vol. 26732685, 2018. Diseases inside and outside the intestine are closely related to the changes in the abundance of Bifidobacterium longum. WebBifidobacterium longum yang kebal antibiotik dapat membantu mengobati penyakit radiasi. This website uses cookies to improve your experience while you navigate through the website. Protective mechanism of Bifidobacterium longum against intestinal inflammation. Application of microbial inoculum downregulates the tumor necrosis factor (TNF) expression, myeloperoxidase activity, and hemorrhagic ulcerative lesions area [41]. 32, no. 11, 2020. 38, 2020. F. Turroni, S. Duranti, C. Milani, G. A. Lugli, D. van Sinderen, and M. Ventura, Bifidobacterium bifidum: a key member of the early human hut microbiota, Microorganisms, vol. 8, pp. 10, pp. Reijman M et al. Co. Mayo, V. Lohrasbi, M. Abdi, A. Asadi et al., The effect of improved formulation of chitosan-alginate microcapsules of Bifidobacteria on serum lipid profiles in mice, Microbial Pathogenesis, vol. Therefore, Bifidobacterium longum can reduce the production of proinflammatory cytokines, inhibit the activation of NF-B induced by TNF-, and improve the symptoms of IBD (Figure 1). B. Nascimento, M. E. R. Andrade et al., Treatment withBifidobacterium longum51A attenuates intestinal damage and inflammatory response in experimental colitis, Beneficial Microbes, vol. G. Bevivino and G. Monteleone, Advances in understanding the role of cytokines in inflammatory bowel disease, Expert Review of Gastroenterology & Hepatology, vol. 218225, 2014. To investigate the alleviative effect of a ropy-exopolysaccharide 2008 Dec;20(12):1551-63. doi: 10.1093/intimm/dxn114. 4, pp. 2, pp. 39, no. 6, p. 555, 2017. 568571, 2014. In addition, probiotic preparations take a long time to be effective [116]. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. 439461, 2000. Bifidobacterium longum are an important probiotic bacteria that are able to colonize the human gastrointestinal tract; this species has been added to a variety of dietary supplements, foods, health products, and drugs for regulating intestinal flora, increasing immune function, improving lipid metabolism, and relieving constipation and anti Goblet cells in the intestine produce mucus to fight off invading pathogens. These cookies will be stored in your browser only with your consent. 4 mg/capsule (1 billion colony-forming units) Promotes digestive health: One capsule daily: INSUFFICIENT RELIABLE EVIDENCE to RATE for Irritable bowel syndrome; Bio-K+ (Bio-K+ International) Lactobacillus acidophilus CL 1285, Lacticaseibacillus casei LBC80R, Lacticaseibacillus rhamnosus CLR2 2, pp. 11, pp. 2. The improvement of gut microbiota composition has been proposed as an effective auxiliary method for the treatment of certain intestinal inflammatory diseases [96]. Changes to the joint usually occur gradually and can get worse over time. * Vitamin C contributes to normal collagen formation for the normal function of cartilage. For IBD patients, oxidative stress occurs with the raise of ROS levels and decline of antioxidant levels, which leads to chronic tissue damage continuously [38, 39] (Figure 1). The present study investigated the mechanism of B. infantis in treating allergic asthma in mice. The abundance of gut microbiota was reduced, and the bifidobacteria supplementation alleviated the changes of gut microbiota induced by DSS [72]. In addition to mechanical and other risk factors, accumulating evidence suggests that the presence of chronic low-grade inflammation has a role in the development of osteoarthritis. R. Bibiloni, R. N. Fedorak, G. W. Tannock et al., VSL#3 probiotic-mixture induces remission in patients with active ulcerative colitis, The American Journal of Gastroenterology, vol. Bifidobacterium longum has also been shown to help prevent constipation, reduce inflammation caused by certain bowel conditions, prevent high cholesterol levels and help prevent the development of certain allergies. 10, no. Injury, overuse of a joint causing repetitive stress, or joint surgery may lead to OA at that site later in life. Scuotto et al. 446, 2021. T. Ulven, Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets, Front Endocrinol, vol. 7, no. Therefore, B. longum can regulate intracellular signaling pathways and decrease the level of IL-1, IL-6, and IL-8, reduce the alterations of the in vitro epithelial barrier induced by DSS, and regulate the inflammatory response [59, 71, 72] (Figure 1). D. C. de Oliveira, A. infantis 157F Bifidobacterium longum subsp. 12, no. Once daily capsule, taken with or without food. P. Martorell, B. Alvarez, S. Llopis et al., Heat-treated Bifidobacterium longum CECT-7347: a whole-cell postbiotic with antioxidant, anti-inflammatory, and gut-barrier protection properties, Antioxidants, vol. 24, pp. 5, p. 2719, 2021. 497505, 2018. S. Wirtz, V. Popp, M. Kindermann et al., Chemically induced mouse models of acute and chronic intestinal inflammation, Nature Protocols, vol. Monoclonal cytokines such as anti-TNF- and IL-6 can also treat IBD, but the high production cost of this method makes it unacceptable for some patients [6]. This molecule reduces the IL-8 response after IL-1 stimulus. The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes. In addition, a Sir2-encoding gene (LTBL16-002010) was also found in B. longum LTBL16, which could improve FOXO-dependent transcription of antioxidant enzymes encoding genes and reduce ROS levels in cells [45]. Arthritis Research UK (2013) Osteoarthritis in general practice. For example, when it was used together with the prebiotic synergy 1, the CD activity and histological score were reduced [104]. Bookshelf H. Steed, G. T. Macfarlane, K. L. Blackett et al., Clinical trial: the microbiological and immunological effects of synbiotic consumption - a randomized double-blind placebo-controlled study in active Crohn's disease, Alimentary Pharmacology & Therapeutics, vol. This observatory evaluate the effect of Bifidobacterium longum 35624 on the quality of life of IBS patients having different subtypes of transit pattern and different level of symptom severity, after a one-month treatment with Bibidobacterium longum 35624, 1x10^9 CFU/capsule, 1 capsule/day. 67, no. BL-Sir2 regulated FOXO3a mediated antioxidant genes, deacetylated H, and increased the activity of manganese superoxide dismutase and catalase and reduced ROS [44]. 1, article e0169847, 2017. 514521, 2007. The anaerobic species and short-chain fatty acid producers depleted, and the facultative anaerobic bacteria increased in the gut of patients [23]. Bifidobacteria are common members of the gastrointestinal tract (GIT), representing ~10% of the adult gut microbiota [ 2, 3 ]. 149156, 2018. In an ethanol-induced gastroenteritis study, the oral administration of B. longum LC67 in mice was found to suppress the TNF- expression and NF-B activation in mucosal cells, restore the gut microbiota disturbance, and alleviate ethanol-induced GI inflammation [28]. 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